Seizures that occur around the menstrual cycle are called catamenial epilepsy. Studies show that changes in seizures are most often in the. Catamenial epilepsy is defined as a pattern of seizures that changes in severity during particular phases of the menstrual cycle, wherein. Epilepsy is a chronic neurological condition characterized by recurrent seizures. Catamenial epilepsy is a subset of epilepsy, which includes women whose.

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Epilepsy types Seizure types. Knowledge of the effects of sex hormones on epilepsy may open new therapeutic approaches, in addition to antiepileptic drugs, for women with catamenial seizures pattern. This page was last edited on 27 Decemberat fatamenial Please review our privacy policy. Because progesterone has mainly been shown to have anticonvulsant effects, and because women with catamenial epilepsy under study often had inadequate luteal-phase or anovulatory cycles, it can be hypothesized that progesterone, progesterone metabolites, or estrogen antagonists may be used in conjunction with current antiepileptic medications, to treat these patients.

Retrieved xatamenial ” https: GABA A receptor alpha4 subunit suppression prevents withdrawal properties of an endogenous steroid. The aim of this review is to report preclinical and clinical evidences about the relationship between female reproductive steroids and epileptic seizures, and to describe treatment approaches for catamenial epilepsy.

Neurosteroid withdrawal model of perimenstrual catamenial epilepsy.

Catamenial epilepsy – Wikipedia

Since at least the Greek times, there has been documented study of women with epilepsy and catameial correlation to the menstrual cycle. Effect of norethisterone on seizures associated with menstruation.


Estradiol facilitates the release of neuropeptide Y to suppress hippocampus- dependent seizures. Unbalanced progesterone and estradiol secretion in catamenial epilepsy.

Menstrual cycle worsening of epileptic seizures in women with symptomatic focal epilepsy.

Enhanced anticonvulsant activity of neuroactive steroids in a rat model of catamenial epilepsy. Because this factor is phase-independent, the modulatory effect of age may arise from factors outside the cyclic effects of the hypothalamic-pituitary- gonadal axis. Females, their estrogens, and seizures. By this measure, approximately one third of women with epilepsy would be classified under the designation of catamenial epilepsy.

Effects of progesterone Animal and humans studies 3839 clearly indicate that catamenial seizures are associated with a rapid decline in progesterone immediately before, during, and after menstruation. Seizure exacerbation associated with inhibition of progesterone metabolism. Anovulatory females do not typically have a midcycle surge of progesterone, but still experience a surge in estrogen.

Belelli D, Lambert JJ. Convulsant actions of the neurosteroid pregnenolone sulfate in mice. Most of the reproductive hormones, including the estrogens, progesterone and testosterone, diminish initially perimenopausebecoming irregular, often showing wide and unpredictable fluctuations. They may be used in women with epilepsy also to prevent unwanted pregnancies.

Catamenial Seizures

Estrogen increases latencies to seizures and levels of 5alpha-pregnan-3alpha-olone in hippocampus of wild-type, but not 5alpha-reductase knockout, mice. The neuroprotective activity of estrogens was then confirmed by several subsequent studies.

Erel T, Guralp O. Clomiphene is an ovulatory stimulant that is used to treat infertility in women with oligoanovulation or anovulation. A variety of therapies for catamenial epilepsy have been proposed, including nonhormonal acetazolamide, cyclical use of benzodiazepines, or conventional antiepileptic drugsand hormonal therapies. Reproductive hormonal changes and catamenial pattern in adolescent females with epilepsy.


Large multicenter trials are needed to identify the most effective treatment for women with catamenial epilepsy. Therefore, it is hypothesized that estrogens may facilitate some forms of catamenial seizures observed during these phases. The effects of estrogen, progesterone, and ionized calcium on seizures during cataenial menstrual cycle of epileptic women.

Ganaxolone Presurgical Study Group. Support Center Support Center. Women with epilepsy who do not follow a catamenial pattern may have an unpredictable increase or decrease in seizure activity in perimenopause and menopause, but women with catamenial epilepsy typically follow a more predictable pattern.

Diagnosis and management of catamenial seizures: a review

Simultaneous assays of progesterone, pregnenolone, dehydroepiandrosterone, testosterone, dihydrotestosterone, cafamenial, oestradiol and oestrone. This is especially the case for catamenlal who experience complex partial seizures. In animal models, the thresholds of limbic seizures in female rats are inversely related to estradiol levels, 22 and intravenous or topical administration of estradiol in rabbits increases spontaneous electrically recorded paroxysmal spike discharges.

Chronology and evolution of temporal lobe epilepsy and endocrine reproductive dysfunction in women: Therefore, this drug can only be administered on an intermittent basis, which is appropriate for catamenial epilepsy but not for ordinary seizure prophylaxis.